Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity
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- K Andries
- Janssen Research Foundation, Beerse, Belgium.
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- B Dewindt
- Janssen Research Foundation, Beerse, Belgium.
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- J Snoeks
- Janssen Research Foundation, Beerse, Belgium.
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- L Wouters
- Janssen Research Foundation, Beerse, Belgium.
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- H Moereels
- Janssen Research Foundation, Beerse, Belgium.
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- P J Lewi
- Janssen Research Foundation, Beerse, Belgium.
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- P A Janssen
- Janssen Research Foundation, Beerse, Belgium.
書誌事項
- 公開日
- 1990-03
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.64.3.1117-1123.1990
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:p>A variety of chemically different compounds inhibit the replication of several serotypes of rhinoviruses (common-cold viruses). We noticed that one of these antiviral compounds, WIN 51711, had an antiviral spectrum clearly distinctive from a consensus spectrum or other capsid-binding compounds, although all of them were shown to share the same binding site. A systematic evaluation of all known rhinovirus capsid-binding compounds against all serotyped rhinoviruses was therefore initiated. Multivariate analysis of the results revealed the existence of two groups of rhinoviruses, which we will call antiviral groups A and B. The differential sensitivity of members of these groups to antiviral compounds suggests the existence of a dimorphic binding site. The antiviral groups turned out to be a reflection of a divergence of rhinovirus serotypes on a much broader level. Similarities in antiviral spectra were highly correlated with sequence similarities, not only of amino acids lining the antiviral compound-binding-site, but also of amino acids of the whole VP1 protein. Furthermore, analysis of epidemiological data indicated that group B rhinoviruses produced more than twice as many clinical infections per serotype than group A rhinoviruses did. Rhinoviruses belonging to the minor receptor group were without exception all computed to lie in the same region of antiviral group B.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 64 (3), 1117-1123, 1990-03
American Society for Microbiology