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- Heather A Jackson
- Heather A Jackson PharmD, Drug Information Specialty Resident, Purdue University/Clarian Health Partners, Indianapolis, IN
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- Amy Heck Sheehan
- Amy Heck Sheehan PharmD, Associate Professor of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University; Drug Information Specialist, Clarian Health Partners
説明
<jats:sec><jats:title>OBJECTIVE</jats:title><jats:p> To describe current data evaluating the effect of vitamin A intake on fracture risk. </jats:p></jats:sec><jats:sec><jats:title>DATA SOURCES</jats:title><jats:p> A literature search using MEDLINE (1966–March 2005) was conducted using the search terms bone density, fractures, osteoporosis, retinol, and vitamin A to identify published studies evaluating the effects of vitamin A on bone. </jats:p></jats:sec><jats:sec><jats:title>DATA SYNTHESIS</jats:title><jats:p> Studies evaluating vitamin A consumption and fracture risk were reviewed. Current data suggest a potential inverse relationship between excess vitamin A consumption and bone mineral density leading to an increased risk for fracture. </jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p> Although current data are limited, consumption of large amounts of vitamin A may be associated with decreased bone mineral density and increased fracture risk. Until further information is available, patients should be made aware of the potential risks of consuming vitamin A in amounts that exceed the recommended dietary allowance. Further research is needed to clarify the relationship between vitamin A and fracture risk. </jats:p></jats:sec>
収録刊行物
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- Annals of Pharmacotherapy
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Annals of Pharmacotherapy 39 (12), 2086-2090, 2005-12
SAGE Publications
