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- Carole L. Yauk
- 1Mutagenesis Section, Environmental and Occupational Toxicology Division;
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- M. Lynn Berndt
- 1Mutagenesis Section, Environmental and Occupational Toxicology Division;
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- Andrew Williams
- 2Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada; and
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- Andrea Rowan-Carroll
- 1Mutagenesis Section, Environmental and Occupational Toxicology Division;
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- George R. Douglas
- 1Mutagenesis Section, Environmental and Occupational Toxicology Division;
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- Martin R. Stämpfli
- 3Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
書誌事項
- 公開日
- 2007-06-01
- DOI
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- 10.1158/0008-5472.can-07-0279
- 公開者
- American Association for Cancer Research (AACR)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Despite the presence of known mutagens and carcinogens in cigarette smoke, there is currently no evidence to show that smoking, or exposure to cigarette smoke, can result in heritable genetic mutation. We show that male mice exposed to mainstream tobacco smoke (MTS) exhibit a significant increase in germ-line mutation frequency in spermatogonial stem cells. We exposed mature male mice to MTS for 6 or 12 weeks and investigated mutations arising in exposed spermatogonial stem cells at the expanded simple tandem repeat locus Ms6-hm. A generalized score test showed a significant treatment effect (P = 0.0214). Ms6-hm mutation frequency was 1.4 and 1.7 times higher in mice exposed to MTS for 6 and 12 weeks, respectively, compared with sham controls. The data suggest that mutations accumulate in the spermatogonial stem cells with extended exposures. Mutation spectra were identical between exposed and sham individuals, supporting the hypothesis that tandem repeat mutations arise through indirect mechanisms of mutation. Mutations in sperm that are passed on to offspring cause permanent, irreversible changes in genetic composition and can persist in future generations. Our research suggests that the consequences of smoking extend beyond the smoker to their nonsmoking descendents. [Cancer Res 2007;67(11):5103–4]</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 67 (11), 5103-5106, 2007-06-01
American Association for Cancer Research (AACR)
