Separation of the optical isomers of a new 1,4‐dihydropyridine calcium channel blocker (LF 2.0254) by liquid and supercritical fluid chromatography

Laurent Siret, Pierre Macaudiere, Nathalie Bargmann‐Leyder, André Tambute, Marcel Caude, Émile Gougeon

doi:10.1002/chir.530060513

Separation of the optical isomers of a new 1,4‐dihydropyridine calcium channel blocker (LF 2.0254) by liquid and supercritical fluid chromatography

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書誌事項

公開日: 1994-01

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DOI

10.1002/chir.530060513

公開者: Wiley

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<jats:title>Abstract</jats:title><jats:p>The four optical isomers of a new calcium channel blocker LF 2.0254 (developed by Laboratoires Fournier) are resolved by chromatography using chiral stationary phases. Two methods are proposed: the first one involving two chiral stationary phases [(S)‐<jats:italic>N</jats:italic>‐(2‐naphthyl)alanine, a Pirkle type CSP and Chiralcel OJ, a cellulose derived CSP] in the liquid chromatographic mode, the second one involving a single CSP (Chiralcel OJ) in the supercritical fluid chromatographic mode. © 1994 Wiley‐Liss, Inc.</jats:p>