Simple Isoquinoline and Benzylisoquinoline Alkaloids as Potential Antimicrobial, Antimalarial, Cytotoxic, and Anti-HIV Agents
書誌事項
- 公開日
- 2001-11
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
-
- 10.1016/s0968-0896(01)00154-7
- 公開者
- Elsevier BV
この論文をさがす
説明
Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents. These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial), 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen atom of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast, anti-HIV activity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium salts.
収録刊行物
-
- Bioorganic & Medicinal Chemistry
-
Bioorganic & Medicinal Chemistry 9 (11), 2871-2884, 2001-11
Elsevier BV
- Tweet
キーワード
- Magnetic Resonance Spectroscopy
- Anti-HIV Agents
- Plasmodium falciparum
- Drug Evaluation, Preclinical
- Antineoplastic Agents
- Microbial Sensitivity Tests
- Gram-Positive Bacteria
- Isoquinolines
- Anti-Bacterial Agents
- Antimalarials
- Mice
- Alkaloids
- Anti-Infective Agents
- Candida albicans
- Gram-Negative Bacteria
- HIV-1
- Animals
- Humans
- Crystallization
- Cell Division
詳細情報 詳細情報について
-
- CRID
- 1362825894794354816
-
- NII論文ID
- 30006742066
-
- ISSN
- 09680896
-
- PubMed
- 11597468
-
- データソース種別
-
- Crossref
- CiNii Articles
- OpenAIRE
