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- Shiyu Luo
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- C. Alexander Valencia
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Jinglan Zhang
- Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;
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- Ni-Chung Lee
- Department of Pediatrics and Medical Genetics, National Taiwan University Hospital, 100 Taipei, Taiwan;
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- Jesse Slone
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Baoheng Gui
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Xinjian Wang
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Zhuo Li
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Sarah Dell
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Jenice Brown
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
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- Stella Maris Chen
- Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;
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- Yin-Hsiu Chien
- Department of Pediatrics and Medical Genetics, National Taiwan University Hospital, 100 Taipei, Taiwan;
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- Wuh-Liang Hwu
- Department of Pediatrics and Medical Genetics, National Taiwan University Hospital, 100 Taipei, Taiwan;
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- Pi-Chuan Fan
- Department of Pediatrics, National Taiwan University Hospital, 100 Taipei, Taiwan;
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- Lee-Jun Wong
- Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;
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- Paldeep S. Atwal
- Department of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic Hospital, Jacksonville, FL 32224
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- Taosheng Huang
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;
説明
<jats:title>Significance</jats:title> <jats:p>The energy-producing organelle mitochondrion contains its own compact genome, which is separate from the nuclear genome. In nearly all mammals, this mitochondrial genome is inherited exclusively from the mother, and transmission of paternal mitochondria or mitochondrial DNA (mtDNA) has not been convincingly demonstrated in humans. In this paper, we have uncovered multiple instances of biparental inheritance of mtDNA spanning three unrelated multiple generation families, a result confirmed by independent sequencing across multiple unrelated laboratories with different methodologies. Surprisingly, this pattern of inheritance appears to be determined in an autosomal dominantlike manner. This paper profoundly alters a widespread belief about mitochondrial inheritance and potentially opens a novel field in mitochondrial medicine.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 115 (51), 13039-13044, 2018-11-26
Proceedings of the National Academy of Sciences
