Limits of detection of SPIO at 3.0 T using <i>T</i><sub>2</sub>* relaxometry

DOI Web Site Web Site 被引用文献4件

書誌事項

公開日
2005-04-20
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/mrm.20435
公開者
Wiley

この論文をさがす

説明

<jats:title>Abstract</jats:title><jats:p><jats:italic>T</jats:italic><jats:sub>2</jats:sub>* relaxometry for quantitative MR imaging is strongly hampered by large‐scale field inhomogeneities, which lead to signal losses and an overestimation of the relaxation rate <jats:italic>R</jats:italic><jats:sub>2</jats:sub>*. This is of particular importance for the sensitive detection of iron oxide contrast agent distributions. To derive an accurate measurement of <jats:italic>T</jats:italic><jats:sub>2</jats:sub>*, a main field inhomogeneity correction is applied: the main field inhomogeneity is derived from multislice <jats:italic>T</jats:italic><jats:sub>2</jats:sub>* relaxometry data and used as an initial value for an iterative optimization, by which the relaxation signal is corrected for each voxel. These corrected <jats:italic>T</jats:italic><jats:sub>2</jats:sub>* maps show reduced influence of the local field variation and contain information about the local SPIO concentration. The method was tested on phantoms and the limit of detection of SPIO labeled cells using <jats:italic>T</jats:italic><jats:sub>2</jats:sub>* relaxometry was estimated in volunteers to be 120 × 10<jats:sup>3</jats:sup> cells/mL (2.4 μg Fe/mL) in the brain and 385 × 10<jats:sup>3</jats:sup> cells/mL (8 μg Fe/mL) in the liver. Magn Reson Med 53:1202–1206, 2005. © 2005 Wiley‐Liss, Inc.</jats:p>

収録刊行物

被引用文献 (4)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ