Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle

DOI Web Site 被引用文献2件
  • M B McChesney
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
  • J H Kehrl
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
  • A Valsamakis
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
  • A S Fauci
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
  • M B Oldstone
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.

書誌事項

公開日
1987-11
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.61.11.3441-3447.1987
公開者
American Society for Microbiology

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説明

<jats:p>Measles virus infection of unstimulated B lymphocytes suppresses both proliferation and differentiation into immunoglobulin-secreting cells. However, mitogenic stimulation of these infected cells results in cell volume enlargement, rapid RNA synthesis, and the expression of cell surface activation antigens 4F2, HLA-DS, and transferrin receptor. The cellular genes c-myc and histone 2B are induced during early G1 and S phase of the cell cycle, respectively, and viral RNA synthesis can be detected during this interval. However, total RNA synthesis is decreased at 48 h after stimulation, and the histone 2B RNA steady-state level at 48 h is fivefold less than that in uninfected cells. This sequence of events defines an arrest in the G1 phase of the cell cycle in measles virus-infected B cells.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 61 (11), 3441-3447, 1987-11

    American Society for Microbiology

被引用文献 (2)*注記

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