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- M. Ryan Corces
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Jeffrey M. Granja
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Shadi Shams
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Bryan H. Louie
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Jose A. Seoane
- Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
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- Wanding Zhou
- Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
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- Tiago C. Silva
- Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Clarice Groeneveld
- Bioinformatics and Systems Biology Laboratory, Polytechnic Center, Federal University of Paraná, Curitiba, PR CEP 80.060-000, Brazil.
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- Christopher K. Wong
- Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California–Santa Cruz, Santa Cruz, CA 95064, USA.
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- Seung Woo Cho
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Ansuman T. Satpathy
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Maxwell R. Mumbach
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Katherine A. Hoadley
- Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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- A. Gordon Robertson
- Canada’s Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
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- Nathan C. Sheffield
- Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
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- Ina Felau
- National Cancer Institute, NIH, Bethesda, MD 20892, USA.
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- Mauro A. A. Castro
- Bioinformatics and Systems Biology Laboratory, Polytechnic Center, Federal University of Paraná, Curitiba, PR CEP 80.060-000, Brazil.
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- Benjamin P. Berman
- Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Louis M. Staudt
- National Cancer Institute, NIH, Bethesda, MD 20892, USA.
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- Jean C. Zenklusen
- National Cancer Institute, NIH, Bethesda, MD 20892, USA.
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- Peter W. Laird
- Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
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- Christina Curtis
- Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
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- William J. Greenleaf
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
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- Howard Y. Chang
- Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
説明
<jats:title>Cancer chromatin accessibility landscape</jats:title> <jats:p> The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces <jats:italic>et al.</jats:italic> used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA samples from 23 cancer types (see the Perspective by Taipale). When the data were integrated with other omics data available for the same tumor samples, inherited risk loci for cancer predisposition were revealed, transcription factors and enhancers driving molecular subtypes of cancer with patient survival differences were identified, and noncoding mutations associated with clinical prognosis were discovered. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav1898">eaav1898</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6413" page="401" related-article-type="in-this-issue" vol="362" xlink:href="10.1126/science.aav3494">401</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 362 (6413), eaav1898-, 2018-10-26
American Association for the Advancement of Science (AAAS)