The +276 Polymorphism of the <i>APM1</i> Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men
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- Lu Qi
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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- Tricia Li
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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- Eric Rimm
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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- Cuilin Zhang
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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- Nader Rifai
- Department of Laboratory Medicine, Children’s Hospital and Harvard Medical School, Boston, Massachusetts
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- David Hunter
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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- Alessandro Doria
- Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts
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- Frank B. Hu
- Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
書誌事項
- 公開日
- 2005-05-01
- DOI
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- 10.2337/diabetes.54.5.1607
- 公開者
- American Diabetes Association
この論文をさがす
説明
<jats:p>Recently, the genetic variability at adiponectin locus (APM1) was associated with cardiovascular risk in patients with type 2 diabetes. We sought to examine the associations of five variants of APM1 gene (C-11365G, A-4034C, A-3964G, T45G, and G276T) with the risk of cardiovascular diseases (CVDs) in a larger cohort of diabetic patients. Of 879 diabetic men from the Health Professionals Follow-up Study, 239 participants developed coronary heart disease or stroke during 14 years of follow-up and 640 CVD-negative subjects were used as control subjects. The risk of CVD was significantly lower in TT homozygotes at locus +276 than in other genotypes under a recessive inheritance model after adjusting for age, BMI, smoking, alcohol consumption, physical activity, aspirin use, HbA1c, and history of hypertension or hypercholesterolemia (odds ratio 0.38 [95% CI 0.18–0.79]; P = 0.009). In the CVD-negative control subjects, the allele 276T was associated with significantly higher plasma adiponectin levels in a dose-dependent pattern (GG 14.8, GT 16.2, and TT 18.8 μg/ml) after adjusting for age, BMI, and other variables (P for trend = 0.0019). In conclusion, our study showed significant associations between APM1 G276T and decreased CVD risk and increased plasma adiponectin levels in diabetic men.</jats:p>
収録刊行物
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- Diabetes
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Diabetes 54 (5), 1607-1610, 2005-05-01
American Diabetes Association