Molecular Epidemiology of Adenovirus Infection among Pediatric Population with Diarrhea in Asia

  • Lei Li
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan
  • Tung Gia Phan
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan
  • Tuan Anh Nguyen
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan
  • Kyo Sun Kim
    Kon‐Kuk University Chung Ju Hospital Chungchongbuk‐Do 380‐701 Korea
  • Jeong Kee Seo
    Seoul National University Children's Hospital Korea
  • Hideaki Shimizu
    Kawasaki City Institute of Public Health Kawasaki Kanagawa 210‐0834 Japan
  • Eiko Suzuki
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan
  • Shoko Okitsu
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan
  • Hiroshi Ushijima
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine The University of Tokyo Bunkyo‐ku Tokyo 113‐0033 Japan

書誌事項

公開日
2005-02
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/j.1348-0421.2005.tb03711.x
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>A total of 3,577 fecal specimens from infants and children with acute gastroenteritis in Japan, Korea and Vietnam during 1998 and 2001 were tested for adenovirus by the ELISA method. Of these, adenovirus was detected in 158 (4.4%). The detection rate of adenovirus was highest in Korea (8.7%, 20/231) followed by 5.0% (100/1,991) in Japan and 2.8% (38/1,355) in Vietnam. All adenoviruses were further serotyped by PCR‐RFLP. The diversity of adenovirus serotypes including Ad2, 3, 5, 8, 31, 40 and 41 was demonstrated. Worth of note was a decrease in the rate of isolation of Ad40 (7.6%, 12/158) and a concomitant increase of Ad41 (63.9%, 101/158) to become the predominant serotype. Another interesting feature of the study was the presence of Ad3 (4.0% and 30%) and Ad8 (8.0% and 20%) in Japan and Korea, respectively, which is mainly associated with keratoconjunctivitis worldwide. Our result underscored the importance of adenovirus in association with acute gastroenteritis in Asian countries.</jats:p>

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