Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
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- Whasil Lee
- Departments of aNeurology,
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- Holly A. Leddy
- Orthopaedic Surgery, and
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- Yong Chen
- Departments of aNeurology,
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- Suk Hee Lee
- Departments of aNeurology,
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- Nicole A. Zelenski
- Orthopaedic Surgery, and
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- Amy L. McNulty
- Orthopaedic Surgery, and
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- Jason Wu
- Neurobiology, and
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- Kellie N. Beicker
- Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; and
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- Jeffrey Coles
- Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708;
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- Stefan Zauscher
- Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708;
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- Jörg Grandl
- Neurobiology, and
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- Frederick Sachs
- Department of Physiology and Biophysics, State University of New York, Buffalo, NY 14214
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- Farshid Guilak
- Orthopaedic Surgery, and
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- Wolfgang B. Liedtke
- Departments of aNeurology,
書誌事項
- 公開日
- 2014-11-10
- 権利情報
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- http://www.pnas.org/site/misc/userlicense.xhtml
- DOI
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- 10.1073/pnas.1414298111
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>Cartilage, a mechanically sensitive tissue that covers joints, is essential for vertebrate locomotion by sustaining skeletal mobility. Transduction of mechanical stimuli by cartilage cells, chondrocytes, leads to biochemical–metabolic responses. Such mechanotransduction can be beneficial for tissue maintenance when evoked by low-level mechanical stimuli, or can have health-adverse effects via cartilage-damaging high-strain mechanical stress. Thus, high-strain mechanotransduction by cartilage mechanotrauma is relevant for the pathogenesis of osteoarthritis. Molecular mechanisms of high-strain mechanotransduction of chondrocytes have been elusive. Here we identify Piezo1 and Piezo2 mechanosensitive ion channels in chondrocytes as transduction channels for high-strain mechanical stress. We verify their functional link to the cytoskeleton as important for their concerted function and offer a remedial strategy by application of a Piezo1/2 blocking peptide, GsMTx4, from tarantula venom.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (47), E5114-, 2014-11-10
Proceedings of the National Academy of Sciences
