Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance
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- Tuo Wei
- Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190 Beijing, People’s Republic of China;
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- Chao Chen
- Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, 13288 Marseille, France;
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- Juan Liu
- Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190 Beijing, People’s Republic of China;
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- Cheng Liu
- Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, 13288 Marseille, France;
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- Paola Posocco
- Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy; and
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- Xiaoxuan Liu
- Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, 13288 Marseille, France;
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- Qiang Cheng
- Laboratory of Nucleic Acid Technology, Institute of Molecular Medicine, Peking University, 100871 Beijing, People’s Republic of China
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- Shuaidong Huo
- Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190 Beijing, People’s Republic of China;
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- Zicai Liang
- Laboratory of Nucleic Acid Technology, Institute of Molecular Medicine, Peking University, 100871 Beijing, People’s Republic of China
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- Maurizio Fermeglia
- Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy; and
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- Sabrina Pricl
- Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy; and
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- Xing-Jie Liang
- Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190 Beijing, People’s Republic of China;
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- Palma Rocchi
- Centre de Recherche en Cancérologie de Marseille, INSERM U1068, F-13009 Marseille, France;
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- Ling Peng
- Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, 13288 Marseille, France;
説明
<jats:title>Significance</jats:title> <jats:p>Nanotechnology-based drug delivery is expected to bring new hope for cancer treatment by enhancing anticancer drug efficacy, overcoming drug resistance, and reducing drug toxicity. In this respect, we developed an innovative drug delivery system based on a self-assembling amphiphilic dendrimer, which can generate supramolecular nanomicelles with large void space in their core to encapsulate anticancer drugs with high loading capacity. The resulting drug-encapsulated nanomicelles can effectively enhance drug potency and combat drug resistance by promoting cellular uptake and decreasing efflux of the anticancer drug. Moreover, this drug delivery system can significantly reduce the systemic toxicity of the free drug. The present study illustrates a successful example of how advances in dendrimer nanotechnology can be advantageously implemented to foster therapeutic perspectives.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 112 (10), 2978-2983, 2015-02-23
Proceedings of the National Academy of Sciences
