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- Humberto Mestre
- Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, U.S.A.
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- Serhii Kostrikov
- Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark
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- Rupal I. Mehta
- Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, U.S.A.
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- Maiken Nedergaard
- Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, U.S.A.
書誌事項
- 公開日
- 2017-08-10
- DOI
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- 10.1042/cs20160381
- 公開者
- Portland Press Ltd.
この論文をさがす
説明
<jats:p>Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces (PVSs), cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered.</jats:p>
収録刊行物
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- Clinical Science
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Clinical Science 131 (17), 2257-2274, 2017-08-10
Portland Press Ltd.