Design Features of a Mitotic Spindle: Balancing Tension and Compression at a Single Microtubule Kinetochore Interface in Budding Yeast

David C. Bouck, Ajit P. Joglekar, Kerry S. Bloom

doi:10.1146/annurev.genet.42.110807.091620

Design Features of a Mitotic Spindle: Balancing Tension and Compression at a Single Microtubule Kinetochore Interface in Budding Yeast

DOI Web Site 被引用文献1件

David C. Bouck

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280;, ,
Ajit P. Joglekar

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280;, ,
Kerry S. Bloom

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280;, ,

抄録

<jats:p> Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells. Hence, segregation errors are thought to be a major cause of tumorigenesis. A study of the physical mechanical basis of chromosome segregation is essential to understand the processes that can lead to errors. Tremendous progress has been made in recent years in identifying the proteins necessary for chromosome movement and segregation, but the mechanism and structure of critical force generating components and the molecular basis of centromere stiffness remain poorly understood. </jats:p>