Transcriptional and Post-Transcriptional Gene Regulation by Long Non-Coding RNA
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- Iain M. Dykes
- School of Clinical Sciences, University of Bristol , Bristol, BS2 8HW , United Kingdom
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- Costanza Emanueli
- School of Clinical Sciences, University of Bristol , Bristol, BS2 8HW , United Kingdom
抄録
<jats:title>Abstract</jats:title> <jats:p>Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.</jats:p>
収録刊行物
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- Genomics, Proteomics & Bioinformatics
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Genomics, Proteomics & Bioinformatics 15 (3), 177-186, 2017-05-19
Oxford University Press (OUP)
