Motor control, habits, complex motor stereotypies, and Tourette syndrome
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- Harvey S. Singer
- Johns Hopkins University School of Medicine Baltimore Maryland
書誌事項
- 公開日
- 2013-10-31
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/nyas.12281
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Tourette syndrome (TS) and primary complex motor stereotypies (CMS) are two relatively common, distinctly different movement disorders of childhood. Despite their frequency, the precise underlying pathophysiological mechanism(s) for tics and stereotypies remains unknown. Both are likely to involve cortical–striatal–thalamo–cortical (CSTC) pathways or their interconnecting brain regions. In recent studies, distinct, separate cortical–striatal pathways have been identified for goal‐directed and habitual behavioral activity with important influences from structures, such as the hippocampus, amygdala, dorsolateral prefrontal cortex, cerebellum, ventral tegmental area, and substantia nigra pars compacta. Determining the specific site of abnormality within these circuits remains an active area of research. At the synaptic level, numerous neurotransmitters are involved in the transmission of messages through CSTC pathways, and many have been proposed as potential pathophysiological mechanisms. Which, if any, transmitter is the primary pathological factor in TS and primary CMS remains to be definitively determined.</jats:p>
収録刊行物
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- Annals of the New York Academy of Sciences
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Annals of the New York Academy of Sciences 1304 (1), 22-31, 2013-10-31
Wiley