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- Jonghwan Jegal
- College of Pharmacy, Pusan National University, Busan, South Korea
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- Sang-a Park
- College of Pharmacy, Pusan National University, Busan, South Korea
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- KiWung Chung
- College of Pharmacy, Pusan National University, Busan, South Korea
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- Hae Young Chung
- College of Pharmacy, Pusan National University, Busan, South Korea
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- Jaewon Lee
- College of Pharmacy, Pusan National University, Busan, South Korea
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- Eun Ju Jeong
- Department of Agronomy & Medicinal Plant Resources, College of Life Sciences and Natural Resources, Gyeongnam National University of Science and Technology, Jinju, South Korea
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- Ki Hyun Kim
- Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea
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- Min Hye Yang
- College of Pharmacy, Pusan National University, Busan, South Korea
説明
<jats:title>Abstract</jats:title> <jats:p>The fruits of Juniperus communis have been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract of J. communis effectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated from J. communis by bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O-β-xylopyranoside isolated from J. communis exhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50 value of 45.15 μM. Further study provided direct experimental evidence for hypolaetin 7-O-β-D-xylopyranoside-attenuated tyrosinase activity in α-MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O-β-D-xylopyranoside from the EtOAc fraction of J. communis was also effective at suppressing α-MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition by J. communis and its constituent. Therapeutic attempts with J. communis and its active component, hypolaetin 7-O-β-D-xylopyranoside, might be useful in treating melanin pigmentary disorders.</jats:p>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 80 (12), 2311-2317, 2016-12-01
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