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- Ben Caplin
- From the Centre for Nephrology, UCL Medical School, London (B.C.); and Nitric Oxide Signalling Group, MRC Clinical Sciences Centre, London, UK (J.L.).
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- James Leiper
- From the Centre for Nephrology, UCL Medical School, London (B.C.); and Nitric Oxide Signalling Group, MRC Clinical Sciences Centre, London, UK (J.L.).
書誌事項
- タイトル別名
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- Markers, Mediators, and Regulators?
抄録
<jats:p>The asymmetric methylarginines inhibit nitric oxide synthesis in vivo by competing with L-arginine at the active site of nitric oxide synthase. High circulating levels of asymmetric dimethylarginine predict adverse outcomes, specifically vascular events but there is now increasing experimental and epidemiological evidence that these molecules, and the enzymes that regulate this pathway, play a mechanistic role in cardiovascular diseases. Recent data have provided insight into the impact of altered levels of these amino acids in both humans and rodents, however these reports also suggest a simplistic approach based on measuring, and modulating circulating asymmetric dimethylarginine alone is inadequate. This review outlines the basic biochemistry and physiology of endogenous methylarginines, examines both the experimental and observational evidence for a role in disease pathogenesis, and examines the potential for therapeutic regulation of these molecules.</jats:p>
収録刊行物
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- Arteriosclerosis, Thrombosis, and Vascular Biology
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Arteriosclerosis, Thrombosis, and Vascular Biology 32 (6), 1343-1353, 2012-06
Ovid Technologies (Wolters Kluwer Health)