Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment
説明
<jats:title>Abstract</jats:title><jats:p>Serotonin 1A (5‐HT<jats:sub>1A</jats:sub>) receptors are found in high densities in prefrontal cortex. However, their distribution within cortical cell populations is unknown in both humans and primates. We used double <jats:italic>in situ</jats:italic> hybridization histochemistry to quantify the percentage of glutamatergic and GABAergic neurons expressing 5‐HT<jats:sub>1A</jats:sub> receptors in human and monkey prefrontal cortex. Moreover, in the case of the monkey, we also quantified the parvalbumin and calbindin GABAergic subpopulations expressing this receptor. 5‐HT<jats:sub>1A</jats:sub> receptor mRNAs were expressed in about 80% of glutamatergic neurons in external layers II and upper III, and in around 50% in layer VI; they were also present in approximately 20% of GABAergic neurons in both species. Although they were found in up to 43% of the calbindin cell subpopulation they were rarely present in parvalbumin cells in monkey prefrontal cortex. The knowledge of the phenotype of the prefrontal cortex (PFC) cells expressing 5‐HT<jats:sub>1A</jats:sub> will help understanding serotonin actions in PFC.</jats:p>
収録刊行物
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- Journal of Neurochemistry
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Journal of Neurochemistry 107 (2), 488-496, 2008-10
Wiley
