<scp>EMT</scp> and <scp>MET</scp>: necessary or permissive for metastasis?
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- Mohit Kumar Jolly
- Center for Theoretical Biological Physics Rice University Houston TX USA
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- Kathryn E. Ware
- Duke Cancer Institute & Department of Medicine Duke University Medical Center Durham NC USA
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- Shivee Gilja
- Duke Cancer Institute & Department of Medicine Duke University Medical Center Durham NC USA
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- Jason A. Somarelli
- Duke Cancer Institute & Department of Medicine Duke University Medical Center Durham NC USA
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- Herbert Levine
- Center for Theoretical Biological Physics Rice University Houston TX USA
Description
<jats:p>Epithelial‐to‐mesenchymal transition (<jats:styled-content style="fixed-case">EMT</jats:styled-content>) and its reverse mesenchymal‐to‐epithelial transition (<jats:styled-content style="fixed-case">MET</jats:styled-content>) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional <jats:styled-content style="fixed-case">EMT</jats:styled-content>/<jats:styled-content style="fixed-case">MET</jats:styled-content> view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.</jats:p>
Journal
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- Molecular Oncology
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Molecular Oncology 11 (7), 755-769, 2017-06-12
Wiley
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Details 詳細情報について
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- CRID
- 1362825895498861824
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- ISSN
- 18780261
- 15747891
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- Web Site
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1878-0261.12083
- https://onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12083
- https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1878-0261.12083
- http://api.wiley.com/onlinelibrary/chorus/v1/articles/10.1002%2F1878-0261.12083
- https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12083
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- Data Source
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- Crossref