Comparison of techniques for measuring  pulse-wave velocity in the rat

Gary F. Mitchell, Marc A. Pfeffer, Peter V. Finn, Janice M. Pfeffer

doi:10.1152/jappl.1997.82.1.203

<jats:p> Mitchell, Gary F., Marc A. Pfeffer, Peter V. Finn, and Janice M. Pfeffer. Comparison of techniques for measuring pulse-wave velocity in the rat. J. Appl. Physiol. 82(1): 203–210, 1997.—We evaluated methods for measuring average and regional pulse-wave velocity along the full length of the aorta in 18-mo-old ether-anesthetized male spontaneously hypertensive rats. Catheter-tip manometers were placed in the ascending and descending thoracic aorta via the right carotid and left femoral arteries, respectively. As the distal catheter was withdrawn at 1-cm intervals, the relationship between distal catheter insertion distance and distance between transducers was determined from the intercept of the insertion distance vs. transmission delay regression line. Methods that assessed the foot-to-foot time delay between pressures accurately predicted the separation between catheters (measured distance of 14.3 cm; intercept of 14.0 ± 0.5 cm; P = not significant) were highly reproducible (coefficient of variation of 2.3% for repeated measurements) and showed minimal variability (range 509 ± 30 to 600 ± 29 cm/s) along the full length of the aorta. Methods that made use of the pressure-pressure transfer function were spatially (range of values along the aorta 367 ± 17 to 722 ± 39 cm/s) and temporally more variable, especially during vasoconstriction with methoxamine, due to the effects of reflected waves. </jats:p>

Comparison of techniques for measuring pulse-wave velocity in the rat

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