Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

DOI Web Site 32 Citations
  • Frank C. Gibson
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Charlie Hong
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Hsin-Hua Chou
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Hiromichi Yumoto
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Jiqiu Chen
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Egil Lien
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Jodie Wong
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...
  • Caroline Attardo Genco
    From the Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass (F.C.G., H.-H.C., H.Y., C.A.G.); Department of Endodontics, Goldman School of Dental Medicine, Boston, Mass (C.H.); School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan (H.-H.C.); Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (J.C.); Institute of Cancer Research and Molecular Biology,...

Description

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> To directly test the connection between periodontal disease and atherosclerosis, apoE <jats:sup>−/−</jats:sup> mice were orally challenged with the periodontal disease pathogen <jats:italic>Porphyromonas gingivalis</jats:italic> or an invasion-impaired <jats:italic>P gingivalis</jats:italic> fimbriae-deficient mutant (FimA−). Both wild-type <jats:italic>P gingivalis</jats:italic> and the FimA− mutant were detected in blood and aortic arch tissue of apoE <jats:sup>−/−</jats:sup> mice by PCR after challenge. ApoE <jats:sup>−/−</jats:sup> mice challenged with wild-type <jats:italic>P gingivalis</jats:italic> presented with increased atherosclerotic plaque and expressed the innate immune response markers Toll-like receptor (TLR)-2 and TLR-4 in aortic tissue. Despite detection of the FimA− mutant in the blood and in aortic arch tissue, apoE <jats:sup>−/−</jats:sup> mice challenged with the FimA− mutant did not present with periodontal disease, upregulation of TLRs, or accelerated atherosclerosis. Furthermore, we demonstrate that immunization to control <jats:italic>P gingivalis</jats:italic> -elicited periodontal disease concomitantly prevents <jats:italic>P gingivalis</jats:italic> -accelerated atherosclerosis. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> We conclude that invasive <jats:italic>P gingivalis</jats:italic> accelerates atherosclerosis. </jats:p>

Journal

  • Circulation

    Circulation 109 (22), 2801-2806, 2004-06-08

    Ovid Technologies (Wolters Kluwer Health)

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