Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein
-
- Tuanlao Wang
- Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore
-
- Wanjin Hong
- Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore
-
- Suzanne R. Pfeffer
- editor
書誌事項
- 公開日
- 2002-12
- DOI
-
- 10.1091/mbc.e02-05-0280
- 公開者
- American Society for Cell Biology (ASCB)
この論文をさがす
説明
<jats:p>We present evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus. Expression of wild-type or GTP-restricted but not GDP-restricted versions of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on its association with the membrane mediated by prenylation and its direct interaction with Rab-interacting lysosomal protein (RILP). This biological activity, mediated by Rab34-RILP interaction, is dependent on Lys82 in the switch I region. Our results have uncovered a novel mechanism for the Golgi apparatus to regulate the spatial distribution of another organelle.</jats:p>
収録刊行物
-
- Molecular Biology of the Cell
-
Molecular Biology of the Cell 13 (12), 4317-4332, 2002-12
American Society for Cell Biology (ASCB)
