The Anticollagenolytic Potential of Lymecycline in the Long‐Term Treatment of Reactive Arthritis

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<jats:title>Abstract</jats:title><jats:p><jats:italic>Objective.</jats:italic> We sought to determine the antiinflammatory properties of lymecycline in the long‐term treatment of reactive arthritis (ReA).</jats:p><jats:p><jats:italic>Methods.</jats:italic> Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfatepolyacrylamide gel electrophoresis.</jats:p><jats:p><jats:italic>Results.</jats:italic> Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase.</jats:p><jats:p><jats:italic>Conclusion.</jats:italic> This non‐antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.</jats:p>

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