Addenbrooke's Cognitive Examination‐Revised for mild cognitive impairment in Parkinson's disease

DOI Web Site Web Site 2 Citations

Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction:</jats:title><jats:p>Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>We investigated the utility of the Addenbrooke's Cognitive Examination‐Revised for detecting mild cognitive impairment (MCI) in PD in an incident population‐representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219).</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Twenty‐two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory‐Revised and Parkinson's Disease Questionnaire 39.</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>This instrument is a useful screening tool for PD‐MCI, and poor performance is significantly related to impaired behavior and quality of life. © 2012 <jats:italic>Movement</jats:italic> Disorder Society</jats:p></jats:sec>

Journal

Citations (2)*help

See more

Report a problem

Back to top