A novel laccase with inhibitory activity towards HIV‐I reverse transcriptase and antiproliferative effects on tumor cells from the fermentation broth of mushroom <i>Pleurotus cornucopiae</i>

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  • Xiangli Wu
    Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China
  • Chenyang Huang
    Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China
  • Qiang Chen
    Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China
  • Hexiang Wang
    State Key Laboratory for Agrobiotechnology and Department of Microbiology China Agricultural University 2 Yuanmingyuan Westroad Beijing 100193 China
  • Jinxia Zhang
    Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China

書誌事項

公開日
2013-10-18
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/bmc.3068
公開者
Wiley

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<jats:title>ABSTRACT</jats:title><jats:p>A novel laccase with a molecular mass of 67 kDa was isolated from the fermentation broth of <jats:italic>Pleurotus cornucopiae</jats:italic> through ion exchange chromatography and gel filtration. The optimal pH and temperature for the laccase was pH 4.2 and 30°C, respectively. The laccase activity was remarkably inhibited by Fe<jats:sup>3+</jats:sup> and Hg<jats:sup>2+</jats:sup>, while it was stimulated by Cu<jats:sup>2+</jats:sup> and Pb<jats:sup>2+</jats:sup>. It inhibited proliferation of the hepatoma cells HepG2 and the breast cancer cells MCF‐7, and the activity of HIV‐I reverse transcriptase with IC<jats:sub>50</jats:sub> values of 3.9, 7.6 and 3.7 μM, respectively. Copyright © 2013 John Wiley & Sons, Ltd.</jats:p>

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