Transcriptional regulation of myeloid-derived suppressor cells

DOI PDF Web Site 被引用文献5件

説明

<jats:title>Abstract</jats:title> <jats:p>Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of tumor angiogenesis, tumor cell invasion, and metastases. Accumulation of myeloid-derived suppressor cells is governed by a network of transcriptional regulators that could be combined into 2 partially overlapping groups: factors promoting myelopoiesis and preventing differentiation of mature myeloid cells and factors promoting pathologic activation of myeloid-derived suppressor cells. In this review, we discuss the specific nature of these factors and their impact on myeloid-derived suppressor cell development.</jats:p>

収録刊行物

被引用文献 (5)*注記

もっと見る

問題の指摘

ページトップへ