Halogen Bonding in Organic Synthesis and Organocatalysis

David Bulfield, Stefan M. Huber

doi:10.1002/chem.201601844

Halogen Bonding in Organic Synthesis and Organocatalysis

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David Bulfield

Department of Chemistry and Biochemistry Ruhr-Universität Bochum Universitätsstraße 150 44801 Bochum Germany
Stefan M. Huber

Department of Chemistry and Biochemistry Ruhr-Universität Bochum Universitätsstraße 150 44801 Bochum Germany

書誌事項

公開日: 2016-07-28

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/chem.201601844

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Halogen bonding is a noncovalent interaction similar to hydrogen bonding, which is based on electrophilic halogen substituents. Hydrogen‐bonding‐based organocatalysis is a well‐established strategy which has found numerous applications in recent years. In light of this, halogen bonding has recently been introduced as a key interaction for the design of activators or organocatalysts that is complementary to hydrogen bonding. This Concept features a discussion on the history and electronic origin of halogen bonding, summarizes all relevant examples of its application in organocatalysis, and provides an overview on the use of cationic or polyfluorinated halogen‐bond donors in halide abstraction reactions or in the activation of neutral organic substrates.</jats:p>