書誌事項
- 公開日
- 2012-05
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1053/j.gastro.2012.01.045
- 公開者
- Elsevier BV
この論文をさがす
説明
Although infection with hepatitis C virus (HCV) has become a leading cause of hepatocellular carcinoma, the mechanisms by which it results in carcinogenesis remain a subject of debate. Here, we explore the possibility that HCV replication impairs cellular DNA damage responses, thereby promoting instability of the infected host cell genome, and that HCV exerts a direct cancer-promoting effect in addition to eliciting immune-mediated inflammation and apoptosis of hepatocytes contributing to hepatocellular carcinogenesis.
収録刊行物
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- Gastroenterology
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Gastroenterology 142 (6), 1274-1278, 2012-05
Elsevier BV