Antineutrophil Cytoplasmic Antibody in Patients with Primary Sjo¨gren's Syndrome
書誌事項
- 公開日
- 1999-05-01
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/s100670050100
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
The incidence, specificity and clinical significance of positivity for serum antineutrophil cytoplasmic antibody (ANCA) was investigated in 60 patients with primary Sjögren's syndrome (SjS). The indirect immunofluorescence (IIF) technique and an enzyme-linked immunosorbent assay (ELISA) were used to measure ANCA. Purified myeloperoxidase (MPO), lactoferrin (LF), cathepsin-G (CTG) and elastase (HLE) served as ANCA antigens for the ELISA. Ten (16.7%) of the 60 SjS patients showed positivity by IIF for perinuclear, but not cytoplasmic, ANCA. Four of the 60 sera were shown to be positive for LF, four for MPO, 0 for CTG and 0 for HLE by ELISA. There was no correlation between ANCA positivity and clinical features. ANCA in patients with SjS might be an epiphenomenon of polyclonal B-cell activation.
収録刊行物
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- Clinical Rheumatology
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Clinical Rheumatology 18 (3), 268-271, 1999-05-01
Springer Science and Business Media LLC
