Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice

DOI Web Site 被引用文献45件
  • R. J. Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St. Dunstans Road, London W6 8RF, UK.
  • S. Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
  • M. Takao
    Department of Neuroscience, Brown University, Providence, RI 02912, USA.
  • D. M. Berson
    Department of Neuroscience, Brown University, Providence, RI 02912, USA.
  • R. G. Foster
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St. Dunstans Road, London W6 8RF, UK.
  • K.-W. Yau
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

抄録

<jats:p>In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non–image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. These animals showed a pupillary light reflex indistinguishable from that of the wild type at low irradiances, but at high irradiances the reflex was incomplete, a pattern that suggests that the melanopsin-associated system and the classical rod/cone system are complementary in function.</jats:p>

収録刊行物

  • Science

    Science 299 (5604), 245-247, 2003-01-10

    American Association for the Advancement of Science (AAAS)

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