Dissection of Signaling Cascades through gp130 In Vivo
説明
We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disrupted, by replacing the mouse gp130 gene with human gp130 mutant cDNAs. The SHP2 signal-deficient mice (gp130F759/F759 were born normal but displayed splenomegaly and lymphadenopathy and an enhanced acute phase reaction. In contrast, the STAT3 signal-deficient mice (gp130FXQ/FXXQ) died perinatally, like the gp130-deficient mice (gp130D/D). The gp130F759/F759 mice showed prolonged gp130-induced STAT3 activation, indicating a negative regulatory role for SHP2. Th1-type cytokine production and IgG2a and IgG2b production were increased in the gp130F759/F759 mice, while they were decreased in the gp130FXXQ/FXXQ immune system. These results indicate that the balance of positive and negative signals generated through gp130 regulates the immune responses.
収録刊行物
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- Immunity
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Immunity 12 (1), 95-105, 2000-01
Elsevier BV
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キーワード
- STAT3 Transcription Factor
- Immunology
- Mice, Transgenic
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Embryonic and Fetal Development
- Interferon-gamma
- Mice
- Antigens, CD
- Cytokine Receptor gp130
- Immunology and Allergy
- Animals
- Humans
- CD40 Antigens
- Acute-Phase Reaction
- Lymphatic Diseases
- Cells, Cultured
- Mice, Knockout
- B-Lymphocytes
- Membrane Glycoproteins
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Intracellular Signaling Peptides and Proteins
- Cell Differentiation
- Hematopoiesis
- DNA-Binding Proteins
- Infectious Diseases
- Astrocytes
- Immunoglobulin G
- Hemocyanins
- Splenomegaly
- Trans-Activators
- Interleukin-4
- Protein Tyrosine Phosphatases
- Signal Transduction
詳細情報 詳細情報について
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- CRID
- 1362825895966031744
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- NII論文ID
- 30010699627
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- ISSN
- 10747613
- http://id.crossref.org/issn/10747613
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- PubMed
- 10661409
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- データソース種別
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- Crossref
- CiNii Articles
- OpenAIRE
