Prehistoric genomes reveal the genetic foundation and cost of horse domestication
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- Mikkel Schubert
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Hákon Jónsson
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Dan Chang
- Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064;
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- Clio Der Sarkissian
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Luca Ermini
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Aurélien Ginolhac
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Anders Albrechtsen
- The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200N Copenhagen, Denmark;
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- Isabelle Dupanloup
- Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland;
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- Adrien Foucal
- Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland;
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- Bent Petersen
- Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark;
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- Matteo Fumagalli
- UCL Genetics Institute, Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;
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- Maanasa Raghavan
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Andaine Seguin-Orlando
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Thorfinn S. Korneliussen
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Amhed M. V. Velazquez
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Jesper Stenderup
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Cindi A. Hoover
- Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;
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- Carl-Johan Rubin
- Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE-751 23 Uppsala, Sweden;
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- Ahmed H. Alfarhan
- Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;
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- Saleh A. Alquraishi
- Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;
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- Khaled A. S. Al-Rasheid
- Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;
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- David E. MacHugh
- Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland;
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- Ted Kalbfleisch
- Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40292;
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- James N. MacLeod
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546;
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- Edward M. Rubin
- Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;
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- Thomas Sicheritz-Ponten
- Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark;
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- Leif Andersson
- Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE-751 23 Uppsala, Sweden;
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- Michael Hofreiter
- Institute for Biochemistry and Biology, Faculty for Mathematics and Natural Sciences, University of Potsdam, 14476 Potsdam, Germany;
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- Tomas Marques-Bonet
- Instituticó Catalana de Recerca i Estudis Avançats, Institut de Biologia Evolutiva (Universitat Pompeu Fabra/Consejo Superior de Investigaciones Cientificas), 08003 Barcelona, Spain;
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- M. Thomas P. Gilbert
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Rasmus Nielsen
- Departments of Integrative Biology and Statistics, University of California, Berkeley, CA 94720
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- Laurent Excoffier
- Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland;
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- Eske Willerslev
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
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- Beth Shapiro
- Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064;
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- Ludovic Orlando
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K Copenhagen, Denmark;
書誌事項
- 公開日
- 2014-12-15
- DOI
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- 10.1073/pnas.1416991111
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>The domestication of the horse revolutionized warfare, trade, and the exchange of people and ideas. This at least 5,500-y-long process, which ultimately transformed wild horses into the hundreds of breeds living today, is difficult to reconstruct from archeological data and modern genetics alone. We therefore sequenced two complete horse genomes, predating domestication by thousands of years, to characterize the genetic footprint of domestication. These ancient genomes reveal predomestic population structure and a significant fraction of genetic variation shared with the domestic breeds but absent from Przewalski’s horses. We find positive selection on genes involved in various aspects of locomotion, physiology, and cognition. Finally, we show that modern horse genomes contain an excess of deleterious mutations, likely representing the genetic cost of domestication.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (52), E5661-, 2014-12-15
Proceedings of the National Academy of Sciences