Hyperphagia and Increased Growth in Rats After Intraventricular Injection of 5,7-Dihydroxytryptamine
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- Charles F. Saller
- Psychobiology Program, Departments of Biology and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
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- Edward M. Stricker
- Psychobiology Program, Departments of Biology and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
書誌事項
- 公開日
- 1976-04-23
- DOI
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- 10.1126/science.1257774
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p>Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86 percent depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.</jats:p>
収録刊行物
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- Science
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Science 192 (4237), 385-387, 1976-04-23
American Association for the Advancement of Science (AAAS)