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- Roberto Burioni
- *Università Vita-Salute San Raffaele and
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- Filippo Canducci
- *Università Vita-Salute San Raffaele and
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- Diego Saita
- *Università Vita-Salute San Raffaele and
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- Mario Perotti
- *Università Vita-Salute San Raffaele and
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- Nicasio Mancini
- *Università Vita-Salute San Raffaele and
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- Donata De Marco
- *Università Vita-Salute San Raffaele and
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- Nicola Clementi
- *Università Vita-Salute San Raffaele and
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- Alaide Chieffo
- †Istituto Scientifico San Raffaele, Milano, Italy,
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- Maurizio Denaro
- ‡Bracco Imaging, San Donato Milanese, Italy; and
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- Domenico Cianflone
- *Università Vita-Salute San Raffaele and
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- Angelo A. Manfredi
- *Università Vita-Salute San Raffaele and
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- Antonio Colombo
- †Istituto Scientifico San Raffaele, Milano, Italy,
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- Attilio Maseri
- §Heart Care Foundation, Firenze, Italy
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- Massimo Clementi
- *Università Vita-Salute San Raffaele and
抄録
<jats:title>Abstract</jats:title> <jats:p>Recent data indicated that adaptive immunity is involved in the process of atherogenesis. Oligoclonal recruitment of T lymphocytes has been described in coronary plaques of patients with acute coronary syndrome. However, the nature of immune response remains to be determined. In the present study, we examined the Ab response in six coronary plaques obtained by endoluminal directional atherectomy. The IgG1/κ-coding gene repertoires of B lymphocytes present in circulating blood and in coronary plaques were cloned and analyzed. In all of the six plaques, we observed 1) a skewed usage of heavy and light IgG1/κ Ab-coding genes, 2) an oligoclonal distribution of VK, JK, and VH, DH, and JH genes with overrepresentation of some rarely used IgG genes, and 3) the unequivocal signs of Ag-driven clonal expansion and evolution of B cells. The data document for the first time the presence of a local Ag-driven clonal evolution of B cells in human atherosclerotic plaques.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 183 (4), 2537-2544, 2009-08-15
The American Association of Immunologists