Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

  • Rafal Dolot
    Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90–363 Lodz, Sienkiewicza 112, Poland
  • Curtis H Lam
    AM Biotechnologies, LLC, 12521 Gulf Freeway, Houston, TX 77034, USA
  • Malgorzata Sierant
    Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90–363 Lodz, Sienkiewicza 112, Poland
  • Qiang Zhao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
  • Feng-Wu Liu
    School of Pharmaceutical Sciences, Zhengzhou University, Science Avenue 100, Zhengzhou 450001, Henan, China
  • Barbara Nawrot
    Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90–363 Lodz, Sienkiewicza 112, Poland
  • Martin Egli
    Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA
  • Xianbin Yang
    AM Biotechnologies, LLC, 12521 Gulf Freeway, Houston, TX 77034, USA

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