Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
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- Iliyan D. Iliev
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Vincent A. Funari
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Kent D. Taylor
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Quoclinh Nguyen
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Christopher N. Reyes
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Samuel P. Strom
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Jordan Brown
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Courtney A. Becker
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Phillip R. Fleshner
- Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Marla Dubinsky
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Jerome I. Rotter
- Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Hanlin L. Wang
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
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- Dermot P. B. McGovern
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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- Gordon D. Brown
- Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences and The Aberdeen Fungal Group, University of Aberdeen, Aberdeen AB24 2ZD, UK.
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- David M. Underhill
- Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
書誌事項
- 公開日
- 2012-06-08
- DOI
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- 10.1126/science.1221789
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>The Mycobiome</jats:title> <jats:p> In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what about fungi? <jats:bold> Iliev <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1314" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1221789">1314</jats:related-article> ) now report that mice and humans, along with several other mammals, contain a resident intestinal population of fungi. Deletion of Dectin-1, which acts as a major innate immune sensor for fungi, led to enhanced susceptibility and worse pathology in a chemically induced model of colitis in mice. A polymorphism in the gene that encodes Dectin-1 has been observed in patients with ulcerative colitis, which hints that, besides the traditional bacterial microbiome, alterations in the “mycobiome” may also play a role in health and disease. </jats:p>
収録刊行物
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- Science
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Science 336 (6086), 1314-1317, 2012-06-08
American Association for the Advancement of Science (AAAS)
