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- Lianfa Shi
- Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
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- Walter K. Nishioka
- La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037, USA.
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- John Th'ng
- Department of Biological Chemistry, University of California, Davis, CA 95616, USA.
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- E. Morton Bradbury
- Department of Biological Chemistry, University of California, Davis, CA 95616, USA.
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- David W. Litchfield
- Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
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- Arnold H. Greenberg
- Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
説明
<jats:p> Activation of the serine-threonine kinase p34 <jats:sup>cdc2</jats:sup> at an inappropriate time during the cell cycle leads to cell death that resembles apoptosis. Premature activation of p34 <jats:sup>cdc2</jats:sup> was shown to be required for apoptosis induced by a lymphocyte granule protease. The kinase was rapidly activated and tyrosine dephosphorylated at the initiation of apoptosis. DNA fragmentation and nuclear collapse could be prevented by blocking p34 <jats:sup>cdc2</jats:sup> activity with excess peptide substrate, or by inactivating p34 <jats:sup>cdc2</jats:sup> in a temperature-sensitive mutant. Premature p34 <jats:sup>cdc2</jats:sup> activation may be a general mechanism by which cells induced to undergo apoptosis initiate the disruption of the nucleus. </jats:p>
収録刊行物
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- Science
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Science 263 (5150), 1143-1145, 1994-02-25
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1362825896365344384
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- NII論文ID
- 30020548178
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
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