Monolayer culture of primary rat hepatocytes on an Arg-Gly-Asp (RGD)-immobilized polystyrene dish express liver-specific functions of albumin production and p-acetamidophenol metabolism the same as for spheroid culture

Hiroyuki Ijima, Yasuo Kakeya

doi:10.1016/j.bej.2008.01.009

Monolayer culture of primary rat hepatocytes on an Arg-Gly-Asp (RGD)-immobilized polystyrene dish express liver-specific functions of albumin production and p-acetamidophenol metabolism the same as for spheroid culture

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書誌事項

公開日: 2008-06

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DOI

10.1016/j.bej.2008.01.009

公開者: Elsevier BV

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説明

Abstract The aim of this study was to evaluate the expression of albumin production and drug metabolism activities of primary rat hepatocytes under a two-dimensional monolayer culture condition formed on a RGD-immobilized culture dish. Albumin production activity on the RGD-immobilized dish (2500 ng cm−2 Pronectin F-coated dish) was 1.6 (p