Human bone perivascular niche-on-a-chip for studying metastatic colonization
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- Alessandro Marturano-Kruik
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Michele Maria Nava
- Department of Chemistry, Materials and Chemical Engineering “G Natta,” Politecnico di Milano, 20133 Milan, Italy;
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- Keith Yeager
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Alan Chramiec
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Luke Hao
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Samuel Robinson
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Edward Guo
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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- Manuela Teresa Raimondi
- Department of Chemistry, Materials and Chemical Engineering “G Natta,” Politecnico di Milano, 20133 Milan, Italy;
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- Gordana Vunjak-Novakovic
- Department of Biomedical Engineering, Columbia University, New York, NY 10032;
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説明
<jats:title>Significance</jats:title> <jats:p>Improved human preclinical models are needed to better predict patients’ responses to anticancer drugs. Increasing the complexity of models may be a successful strategy only if crucial components of a tumor are identified, replicated, and controlled in vitro. We developed a perivascular niche to study metastatic colonization of the bone. Using a microfluidic chip, we exposed the niche to interstitial flow, oxygen gradients, and external forces, and established a dense vascular network. Cancer cells colonizing the bone resisted targeted therapy by entering a slow proliferative state. We expect that microfluidic niche-on-chip models will facilitate the development of drugs targeting persistent tumor cells into the bone and help manage the risk of metastatic relapse.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 115 (6), 1256-1261, 2018-01-23
Proceedings of the National Academy of Sciences
