Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.
Abstract
<jats:p>The DNA templates containing immediate early (IE) genes of human cytomegalovirus (CMV) were transcribed in vitro by using a HeLa cell extract. When IE region 1, 2, and 3 were used, transcription was detected qualitatively only from IE region 1. Transcription was detected with DNA representing IE region 2 when the IE region 1 promoter was not present. DNA sequence analysis of the upstream regulatory region of IE region 1 detected two distinct repeats of 19 and 18 nucleotides, both being repeated four times. A putative cruciform structure could form through the surrounding sequences with each 18-nucleotide repeat being located in the unpaired region. The potential secondary structure and the repeat sequences in the regulatory region of IE region 1 are presumably related to the high level of transcription of this IE gene.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 81 (3), 659-663, 1984-02
Proceedings of the National Academy of Sciences
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Details 詳細情報について
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- CRID
- 1363107368369835392
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- NII Article ID
- 30016276660
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- ISSN
- 10916490
- 00278424
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- Data Source
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- Crossref
- CiNii Articles