A Novel Hemoglobin‐Based Oxygen Carrier, Polymerized Porcine Hemoglobin, Inhibits H<sub>2</sub>O<sub>2</sub>‐Induced Cytotoxicity of Endothelial Cells
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<jats:title>Abstract</jats:title><jats:p>Hemoglobin‐based oxygen carriers (HBOCs), with their capacity for delivering oxygen, could potentially function as red blood cell substitutes or primary resuscitation solutions. However, there has been some concern regarding redox‐related safety issues of HBOCs. The present study describes a novel function of polymerized porcine hemoglobin (pPolyHb) in protecting a human umbilical vein endothelial cell line from H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>‐induced cytotoxicity. Through the examination of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> consumption and ferrylhemoglobin formation, we found that pPolyHb exhibits antioxidant activity, suggesting that pPolyHb may protect cells from free radical‐induced cell damage. Additionally, we investigated the effect of pPolyHb on H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>‐induced cell cytotoxicity, and found that pPolyHb significantly inhibits H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>‐mediated endothelial cell damage as well as apoptosis. Thus, pPolyHb may be developed as a new HBOC in the future.</jats:p>
収録刊行物
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- Artificial Organs
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Artificial Organs 36 (2), 151-160, 2011-09-26
Wiley
