Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

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  • Navin Maswood
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Jennifer Young
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Edward Tilmont
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Zhiming Zhang
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Don M. Gash
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Greg A. Gerhardt
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Richard Grondin
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • George S. Roth
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Julie Mattison
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Mark A. Lane
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Richard E. Carson
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Robert M. Cohen
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Peter R. Mouton
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Christopher Quigley
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Mark P. Mattson
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...
  • Donald K. Ingram
    Laboratories of Neurosciences and Experimental Gerontology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224; Department of Anatomy and Neurobiology and the Morris K. Udall Parkinson's Disease Research Center of Excellence, University of Kentucky, 800 Rose Street, Lexington, KY 40536; PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Neuroimaging Section, Geriatric Psychiatry Branch, National...

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<jats:p>We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet after which they were subjected to treatment with a neurotoxin to produce a hemiparkinson condition. After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine (DA) and DA metabolites in the striatal region. Increased survival of DA neurons in the substantia nigra and improved manual dexterity were noted but did not reach statistical significance. Levels of glial cell line-derived neurotrophic factor, which is known to promote the survival of DA neurons, were increased significantly in the caudate nucleus of CR monkeys, suggesting a role for glial cell line-derived neurotrophic factor in the anti-Parkinson's disease effect of the low-calorie diet.</jats:p>

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