Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque

  • Raffaele De Palma
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Francesco Del Galdo
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Gianfranco Abbate
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Massimo Chiariello
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Raffaele Calabró
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Lavinia Forte
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Giovanni Cimmino
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Maria Francesca Papa
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Maria Giovanna Russo
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Giuseppe Ambrosio
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Claudio Giombolini
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Isabella Tritto
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Salvatore Notaristefano
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Liberato Berrino
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Francesco Rossi
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...
  • Paolo Golino
    From the Department of Clinical and Experimental Medicine (R.D.P., F.D.G., G.A., M.F.P.), Department of Experimental Medicine, Section of Pharmacology (L.B., F.R.), and Department of Cardiothoracic and Respiratory Sciences, Section of Cardiology (R.C., L.F., G.C., M.G.R., P.G.), Second University of Naples, Naples; Department of Internal Medicine and Cardiovascular Sciences (M.C.), Division of Cardiology, University of Naples “Federico II”, Naples; and the Division of Cardiology (G.A., C.G., I.T., S...

書誌事項

タイトル別名
  • Evidence for a Local, Intracoronary Immunologic Mechanism

抄録

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Recent studies indicate that T-cell activation may play an important role in the pathophysiology of acute coronary syndromes (ACS). However, although those studies detected T-cell expansion in peripheral blood cells, demonstration of specific T-cell expansion within the plaque of patients with ACS is lacking. The present study aims to address whether a specific, immune-driven T-lymphocyte recruitment occurs within the unstable plaque of patients with ACS. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> We simultaneously examined the T-cell repertoire using CDR3 size analysis both in coronary plaques (obtained by directional atherectomy) and in peripheral blood of patients with either ACS (n=11) or chronic stable angina (n=10). Unstable plaques showed a 10-fold increase in T-cell content by quantitative PCR. Using spectratyping analysis, we found several specific T-cell clonotype expansions only in unstable plaque from each patient with ACS, indicating a specific, antigen-driven recruitment of T cells within unstable lesions. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> For the first time, T-cell repertoire was investigated directly into coronary plaques; using this approach, we demonstrate that coronary plaque instability in the setting of ACS is associated with immune-driven T-cell recruitment, specifically within the plaque. </jats:p>

収録刊行物

  • Circulation

    Circulation 113 (5), 640-646, 2006-02-07

    Ovid Technologies (Wolters Kluwer Health)

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