Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
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- Issam Ben-Sahra
- Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
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- Jessica J. Howell
- Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
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- John M. Asara
- Division of Signal Transduction, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
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- Brendan D. Manning
- Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
説明
<jats:title>Coordinating Metabolism</jats:title> <jats:p> Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the protein kinase mTORC1 (mechanistic target of rapamycin complex 1). <jats:bold> Ben-Sahra <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6125" page="1323" related-article-type="in-this-issue" vol="339" xlink:href="10.1126/science.1228792">1323</jats:related-article> , published online 21 February) and <jats:bold> Robitaille <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6125" page="1320" related-article-type="in-this-issue" vol="339" xlink:href="10.1126/science.1228771">1320</jats:related-article> , published online 21 February) independently identified a key target of mTORC1—carbamolyl-phosphate synthase 2, or CAD, the rate-limiting enzyme for de novo synthesis of pyrimidines. Metabolomic profiling and phosphoproteomic analyses of normal cells and cells lacking signaling by mTORC1 converged on CAD as a key point at which growth-promoting signals also ramp up production of nucleic acids. </jats:p>
収録刊行物
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- Science
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Science 339 (6125), 1323-1328, 2013-03-15
American Association for the Advancement of Science (AAAS)
