Fine mapping of genome activation in bovine embryos by RNA sequencing

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<jats:title>Significance</jats:title> <jats:p>Gene expression profiling is widely used to get insight into mechanisms of early embryonic development and to characterize embryos generated by various techniques or exposed to different culture conditions. Transcripts in early embryos may be of maternal or embryonic origin, which is difficult to distinguish by conventional techniques. RNA sequencing in bovine oocytes and embryos facilitated mapping of the onset of embryonic expression for almost 7,400 genes. The timing of embryonic gen(om)e activation offers an additional level of information for embryo biosystems research and for detecting disturbances of early development due to genetic, epigenetic, and environmental factors.</jats:p>

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