The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis
説明
Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.
収録刊行物
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- Cell
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Cell 107 (6), 789-800, 2001-12
Elsevier BV
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キーワード
- Matrix Metalloproteinases, Membrane-Associated
- Down-Regulation
- Mice, Nude
- Neovascularization, Physiologic
- Matrix Metalloproteinase Inhibitors
- GPI-Linked Proteins
- Transfection
- Muscle, Smooth, Vascular
- Mice
- Matrix Metalloproteinase 14
- Tumor Cells, Cultured
- Animals
- Humans
- Cells, Cultured
- Membrane Glycoproteins
- Neovascularization, Pathologic
- Biochemistry, Genetics and Molecular Biology(all)
- Metalloendopeptidases
- Neoplasms, Experimental
- Embryo, Mammalian
- Immunohistochemistry
- Matrix Metalloproteinases
- Extracellular Matrix
- Matrix Metalloproteinase 9
- Gene Targeting
- Mutation
- Matrix Metalloproteinase 2
- Neoplasm Transplantation
詳細情報 詳細情報について
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- CRID
- 1363107368957864192
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- NII論文ID
- 80012829412
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- ISSN
- 00928674
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- PubMed
- 11747814
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- データソース種別
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- Crossref
- CiNii Articles
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