Randomized Phase II Trial Comparing Amrubicin With Topotecan in Patients With Previously Treated Small-Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 0402
-
- Akira Inoue
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Shunichi Sugawara
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Koichi Yamazaki
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Makoto Maemondo
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Toshiro Suzuki
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Kazunori Gomi
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Shingo Takanashi
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Chieko Inoue
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Minoru Inage
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Hiroshi Yokouchi
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Hiroshi Watanabe
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Toumei Tsukamoto
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Yasuo Saijo
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Osamu Ishimoto
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Fumihiro Hommura
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
-
- Toshihiro Nukiwa
- From the Department of Respiratory Medicine, Sendai Kousei Hospital, Sendai; First Department of Medicine, Hokkaido University School of Medicine; Department of Respiratory Medicine, Sapporo City General Hospital, Sapporo; Division of Respirology and Chest Surgery, Miyagi Cancer Center, Natori; Department of Respiratory Medicine, Isawa Hospital, Oshu; Department of Cardiology, Respiratory Medicine, and Nephrology, and Department of Medical Oncology, Hirosaki University Graduate School of Medicine,...
Description
<jats:sec><jats:title>Purpose</jats:title><jats:p> Amrubicin, a new anthracycline agent, and topotecan are both active for previously treated small-cell lung cancer (SCLC). No comparative study of these agents has been reported. This randomized phase II study was conducted to select amrubicin or topotecan for future evaluation. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Patients with SCLC previously treated with platinum-containing chemotherapy were randomly assigned to receive amrubicin (40 mg/m<jats:sup>2</jats:sup> on days 1 through 3) or topotecan (1.0 mg/m<jats:sup>2</jats:sup> on days 1 through 5). Patients were stratified by Eastern Cooperative Oncology Group performance status (0, 1, or 2) and type of relapse (chemotherapy sensitive or refractory). The primary end point was overall response rate (ORR), and secondary end points were progression-free survival (PFS), overall survival, and toxicity profile. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> From February 2004 to July 2007, 60 patients were enrolled, and 59 patients (36 patients with sensitive and 23 patients with refractory relapse) were assessable for efficacy and safety evaluation. Neutropenia was severe, and one treatment-related death owing to infection was observed in the amrubicin arm. ORRs were 38% (95% CI, 20% to 56%) for the amrubicin arm and 13% (95% CI, 1% to 25%) for the topotecan arm. In sensitive relapse, ORRs were 53% for the amrubicin arm and 21% for the topotecan arm. In refractory relapse, ORRs were 17% for the amrubicin arm and 0% for the topotecan arm. Median PFS was 3.5 months for patients in the amrubicin arm and 2.2 months for patients in the topotecan arm. Multivariate analysis revealed that amrubicin has more influence than topotecan on overall survival. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Amrubicin may be superior to topotecan with acceptable toxicity for previously treated patients with SCLC. Further evaluation of amrubicin for relapsed SCLC is warranted. </jats:p></jats:sec>
Journal
-
- Journal of Clinical Oncology
-
Journal of Clinical Oncology 26 (33), 5401-5406, 2008-11-20
American Society of Clinical Oncology (ASCO)
- Tweet
Details 詳細情報について
-
- CRID
- 1363107369053903232
-
- ISSN
- 15277755
- 0732183X
- http://id.crossref.org/issn/0732183X
-
- Data Source
-
- Crossref