PULMONARY VASOMOTOR RESPONSES OF ISOLATED PERFUSED CAT LUNGS TO ANOXIA AND HYPERCAPNIA

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<jats:p>1. A method for perfusing isolated cats' lungs with the animal's own heparinized blood is described, with some observations on the condition of the lungs during and after perfusion.</jats:p><jats:p>2. The pulmonary vasomotor responses to inhalation of various gas mixtures have been studied during perfusion of the pulmonary vessels at constant volume inflow.</jats:p><jats:p>3. Inhalation of gas mixtures containing 5–10 per cent. CO<jats:sub>2</jats:sub> produces pulmonary vasoconstriction, as shown by an increase of pulmonary arterial pressure.</jats:p><jats:p>4. Inhalation of gas mixtures containing less than 15 per cent. O<jats:sub>2</jats:sub> also produces a pressor response.</jats:p><jats:p>5. Ventilation of the lungs with pure O<jats:sub>2</jats:sub> has no effect under the conditions of the experiments.</jats:p><jats:p>6. Ventilation of the lungs with pure neon or H<jats:sub>2</jats:sub> produces similar effects to that produced by pure N<jats:sub>2</jats:sub>.</jats:p><jats:p>7. The pulmonary vasomotor responses to CO<jats:sub>2</jats:sub> and O<jats:sub>2</jats:sub> lack are not abolished by dihydroergotamine or atropine.</jats:p>

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